The mean ± SD number of simultaneous IV solutions was 2.8 ± 1.6. We used data from 175,993 ICU drug combinations, with 2251 unique combinations received by 2715 consecutive ICU patients. The number of lumens required by the conventional procedure (L CONV) and multiplex algorithm (L MX) were compared. The conventional scheduling procedure executed by ICU nurses was used for comparison.
MethodsĪ multiplex algorithm was developed that schedules the alternating IV administration of multiple incompatible IV solutions through a single lumen, taking compatibility-related, pharmacokinetic and pharmacodynamic constraints of the relevant drugs into account. Our objective was to develop and evaluate an algorithm designed to reduce the number of intravenous lumens required in multi-infusion settings by multiplexing the administration of various parenteral drugs and solutions. When the number of available lumens is too low to facilitate the safe administration of these solutions, additional (peripheral) IV catheters are often required, causing physical discomfort and increasing the risk for catheter related complications. As drugs or their solvents are frequently chemically incompatible, many solutions must be administered through separate lumens. Multi-drug intravenous (IV) therapy is one of the most common medical procedures used in intensive care units (ICUs), operating rooms, oncology wards and many other hospital departments worldwide.
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